Inhaled hydrogel-based microspheres for management of COVID-19 : A new sweeper biological platform

The cytokine storm caused by SARS-CoV-2 infection threatens the condition of patients, even leading to death. In a recent issue of Matter, Prof. Wenguo Cui and co-workers have prepared lung-sweeper inhaled hydrogel microspheres for intratracheal neutralization of COVID-19 and cytokine storm calming, which could be applied for antiviral tissue regeneration, drug delivery, and disease diagnosis.Non peer reviewe

Bio-Nanomedicine for Cancer Therapy Preface

Non peer reviewe

Introduction to the RSC Advances themed collection on Nanomaterials in drug delivery

Professor Helder A. Santos and Dr Irina N. Savina introduce the RSC Advances themed collection on Nanomaterials in drug delivery.Non peer reviewe

Metabolism of the Antituberculosis Drug Ethionamide

Ethionamide (ETH) is an important second-line antituberculosis drug used for the treatment of patients infected with multidrug-resistant Mycobacterium. Although ETH is a structural analogue of isoniazid (INH), both are pro-drugs that need to be activated by mycobacterial enzymes to exert their antimicrobial activity. ETH mechanism of action is thought to be identical to INH although the pathway of activation is distinct from that of INH. ETH is activated by an EthA enzyme, leading to the formation of an S-oxide metabolite that has considerably better activity than the parent drug. This review comprehensively examines the aspects related with the metabolism of ETH since its discovery up to today

Nanoparticle with super high-drug loading capacity and manufacturing method thereof

A nanoparticle, a manufacturing method, and an apparatus for the manufacturing method. The nanoparticle comprises a nano-nucleus containing an active pharmaceutical ingredient, and an outer shell controlling the release of a pharmaceutical product. The mass of the active pharmaceutical ingredient comprises 30-85% of the mass of the entire nanoparticle. The nanoparticle has a diameter of 50-2,000 nm